Tecfidera® (Dimethyl fumarate)

The Active Ingredient in Tecfidera is dimethyl fumerate, which works to reduce MS relapses and slow the progression of RRMS. Tecfidera reduces the inflammation in the brain caused by MS and helps to protect the cells that form the
myelin against attacks which may damage it.

It is thought that Tecfidera does this by turning on an antioxidant mechanism in the body which deactivates and removes free radicals (generated by inflamation) that are damaging the myelin.

TECFIDERA cannot repair damage that has already been caused by MS. When you start TECFIDERA you might not notice an improvement, but TECFIDERA may still be working to help prevent your MS from becoming worse.

How is Tecfidera administered?  

Tecfidera comes in a capsule that is taken twice a day; one capsule in the morning and the second (capsule) in the evening.

The starting dose is one 120mg capsule, twice a day for 7 days. After the first 7 days a regular dose of one 240mg capsule is taken twice a day. It is important to take as perscribed by your doctor, to take whole and with a glass of water. In no circumstances should you crush, divide or dissolve the capsule or its contents.

Side Effects?

Tell your doctor or pharmacist if you notice any of the following and they worry you:

• reddening of the face or body feeling warm, hot, burning or itchy (flushing)
• loose stools (diarrhoea)
• feeling sick (nausea)
• stomach pain or stomach cramps
• inflammation of the lining of the intestines (gastroenteritis)
• being sick (vomiting)
• indigestion (dyspepsia)    • inflammation of the lining of the stomach (gastritis)
• gastrointestinal disorder
• burning sensation
• hot flush, feeling hot
• itchy skin (pruritus)
• rash
• pink or red blotches on the skin (erythema)

The above list includes the more common side effects of your medicine.  

If any of these persist or worsen, talk to your doctor as they may also be due to an infection or allergic reaction.

Tell your doctor as soon as possible if you notice the following:
• signs of infection (e.g. unexplained fever, severe diarrhoea).

Serious side effects that may require medical attention. Serious side effects are rare.


If any of the following happen, tell your doctor immediately or go to Emergency at your nearest hospital:
• swelling of your face, lips, tongue or other parts of the body
• shortness of breath, wheezing, difficulty breathing, chest pain or discomfort.

The above list includes very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are very rare.

Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

More Information:

Tecfidera Website -
Medsafe Information Sheet -